Background and aim: Diabetes mellitus is a Metabolic disease with multiple complications. Skin Tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients with skin Tags.Materials and methods: This descriptive study was done on 100 patients with skin Tags. The investigation included fasting blood sugar (FBS) and glucose tolerance test (OTT).Results: 66 patients had normal FBS, 27 had diabetes mellitus, 5 had impaired OTT and 2 had impaired fasting glucose. Over all, 34 had abnormal glucose Metabolism, 7 were unaware of their Metabolic abnormality. Among 40 hospitalized patients 50% had abnormal glucose Metabolism meanwhile 23.3% of 60 outpatients had this abnormality (p<0.01). No association was seen between BMI, obesity, gender, location and number of skin Tags with abnormal Metabolism of glucose.Conclusion: It is recommended to consider skin Tags as a cetaceous marker for abnormality of glucose Metabolism.

Introduction: Skin Tags are small, benign, soft and pedunculated skin tumors. A possible association with impaired carbohydrate Metabolism has been suggested in previous studies, but the results are not conclusive. This study was performed in order to determine association between skin Tag and diabetes mellitus.Materials and Methods: This study was carried out on 80 patients with skin Tags as a case group and 80 patients without skin Tags as a control group that they were referred to Semnan dermatological clinics. Then fasting blood sugar (FBS) were checked out in both two groups. In addition, height and weight were measured in all patients and body mass index (BMI) calculated for each of the patient.Results: 43.8% and 55% of patients were respectively female in the case group and the control group.Age mean (±SD) was 44.3±16.6 and 37.3±18.9 years in the case and control group, respectively. BMI mean (±SD) index was 28.0±4.3kg/m2 in the patients with skin Tag, whereas, it was 25.5±5.1 kg/m² in the patients without skin Tag (P=0.001). Patients with skin Tag had higher frequency of diabetes than patients in the control group (27.5% vs.5%) and also the case group showed a higher frequency of pre diabetes than the control group (20% vs.15%). The probability of presence of diabetes mellitus in the patients with skin Tag was 6.82 times more than the patients in the control group (Odds ratio=6.82, 95% Confidence interval: 2.06-22.56, P=0.002).Conclusion: Our data suggest that there is an association between skin Tag and diabetes mellitus. Therefore, screening of patients with skin Tag is recommended for early diagnosis diabetes mellitus.

Skin Tags are skin-colored, asymptomatic, pedunculated lesions located at the neck, axillae or groin. It affects any age, including infants. We report a 60-year-old Iranian woman with a giant pedunculated skin Tag on the left thigh for 10 years. It measured 10 cm in length and 7 cm in width, distally.